L-Histidine is an amino acid from which Histamine is derived. L-Histidine is an amino acid that the human body cannot manufacture, hence, it must be obtained from your diet, which is generally deficient, or from supplements which you can purchase. A discussion of Histamine and it's role in the sexuality of humans follows with references annotated.
A hormone/chemical transmitter (biogenic monoamine, similar to serotonin, epinephrine, norepinephrine ) involved in local immune responses, regulating stomach acid production and in allergic reactions as a mediator of Immediate Hypersensitivity . When released from mast cells, histamine causes vasodilation (relaxation or dilation of the blood vessel walls) !
The influence of the endocrine, neurotransmitter, and central nervous systems influences the male and female sexual functions for sexual desire, arousal, and orgasm or ejaculation stages of sexual responding. Endocrine factors include the following: androgens, estrogens, progesterone, prolactin, oxytocin, cortisol, and pheromones. Neurotransmitters and neuropeptides include nitric oxide (see L-Argingine), serotonin, dopamine (see Uprima), epinephrine, norepinephrine, opioids, acetylcholine, histamine, and gamma-amino-butyric acid (Gaba)1.
Recent advances in the neurobiology of sexual behavior have helped to refine our understanding of the neuroanatomical, neuroendocrine and neurochemical systems that modulate responses to sexual stimulation. Both appetitive and consummatory sexual behaviors have been studied in several laboratory species and in humans using traditional and novel behavioral paradigms. New knowledge has emerged concerning the role of hypothalamic (dopamine & Uprima), limbic and brainstem structures, neuropeptides, brain monoamines and nitric oxide (see L-Argingine) in the control of partner preference, sexual desire, erection, copulation, ejaculation, orgasm and sexual satiety (satisfaction).2
The human sexual response is a complicated biopsychosocial phenomenon in which internal and external stimuli are modulated by the central and peripheral nervous system, resulting in a cascade of biochemical, hormonal and circulatory changes that lead to cognitive and physical sexual arousal. Current knowledge of the relationships between central processes, mediated by neuropeptides and neurotransmitters, and the hypothalamo-pituitary-gonadal axis indicates that they are all involved. Hormonal aspects of sexual arousability and sexual excitement are mainly related to androgens (that is, the male hormones). The possible influences of hormonal therapies such as hormonal contraception and perimenopausal hormone suplementation are involved. The main conclusion is that clinicians should be aware of possible sexual problems resulting from changes in circulating sex hormone binding globulin and free testosterone in men and women due to endogenous (generated in the body) or exogenous (introduced into the body from external sources such as supplements) hormonal changes.3
Dopamine and serotonin are the neurotransmitters most directly involved in sexual activity. Dopamine plays a stimulatory role while serotonin has an inhibitory effect (That's why antidepressant Selective Serotonin Reuptake Inhibitors such as Prozac, Paxil, etc. can cause impotence). The two monoaminergic systems modulate the secretion of many hormones such as testosterone and endorphins (chemical compounds that occur naturally in the brain and have pain relieving properties similar to those of the opiates. They are thought to be concerned with controlling the activity of the endocrine glands) and are involved in sexual functional capacity. Furthermore, hormones influence synthesis and storage of brain neurotransmitters. Impotence can often be associated to clinical depression and altered neurotransmitter function. Moreover, stress represents an unbalance between various neurotransmitter systems and can induce impotence especially when disorders of the endorphinic system are present. Replacement therapy is based upon the understanding of these basic concepts. Impotence due to an underlying depressive illness must be treated with dopaminergic antidepressant drugs; while in stressful conditions a good response to the naloxone test is the preliminary criterion to subsequent naltrexone treatment. When a hormonal deficiency has been proved, the hormone replacement therapy is of course highly effective (gonadotropins in hypogonadotropic syndromes, testosterone in aging, etc.). Finally, idiopathic (denoting a disease or condition the cause of which is not known or that arises spontaneously) impotence could be treated by a Dopamine agonist (Editors Note:Such as Uprima) and/or serotonin antagonist (reduces serotonin) drugs either alone or better yet in association with psychotherapy.5
The corpora cavernosa (CC) muscles of the human penis and their structural arrangements are essential for the physiology of erection. Contraction of this muscle causes detumescence (the reverse of erection), and relaxation, tumescence (swelling or erection). The motor excitatory neurotransmission is adrenergic, acting through the alpha adrenoceptors. Continuous adrenergic transmitter noradrenaline (Norepinephrine) release is necessary for the maintenance of non-erectile (contractile) state of the penis. (Editors note: Contrarily, excessively high levels of noradrenaline (Norepinephrine) could cause a permanent non-erect state, i.e. impotence) The inhibitory neurotransmitter that relaxes CC muscle to produce erection is nitrergic i.e., the chemical messenger being nitric oxide (See L-Argingine). The latter can also be released from cavernous endothelium. Presence of NO increases intracellular cGMP through activation of the enzyme guanylate cyclase. This causes relaxation of CC muscle. Phosphodiesterase type 5 (PDE5) is responsible for the degradation of cGMP and regulation of CC muscle tone. Specific PDE inhibitors such as sildenafil & Cialis enhance the intracellular cGMP to improve erection. Increase in intracellular cAMP can also bring about pharmacological (drug induced) erection in man (e.g. PGE1, papaverine and histamine). Inhibition of excessive adrenergic tone with appropriate alpha-adrenergic blocking agents (e.g. phentolamine) can also contribute to the onset of pharmacological erection.6
Editors suggestions: Work with your doctor!
Have your Neuroregulatory Brain chemicals tested. Click
Here. Look for high levels of Norepinephrine,
Serotonin and low levels of Dopamine. Also test for Testosterone.
© 1998-2014 by The Hormone Shop, LLC.
This Site does not endorse any product advertised on
Disclaimer: The Hormone Shop LLC assumes no liability, whether under a theory of contract, tort, negligence, product liability or otherwise. In no event shall The Hormone Shop LLC be liable for any direct or indirect, consequential, incidental, special, punitive or exemplary damages, or for any loss incurred due to results or comments that are reported or the use of collection materials that are supplied, or any prescriptions regardless of whether The Hormone Shop LLC knew or should have known of the possibility of such damages. Furthermore, in no event shall The Hormone Shop LLC's total cumulative liability exceed The Hormone Shop LLC's net profit on any specific product, sample or consultation giving rise to the liability. The Hormone Shop LLC specifically assumes no liability incurred by any 3rd party associate and if you are reading this web site in a language other that English it has been machine translated by SYSTRAN who strives to achieve the highest possible accuracy, however no automated translation is perfect nor is it intended to replace human translators. Users should note that the quality of the source text significantly affects the translations and The Hormone Shop LLC assumes no liability for incorrect or misleading translations. The questions and comments appearing in the "Discussion Group Forum" are strictly from unknown or unidentified sources and the reader/participant should be aware that credentials from any source are completely lacking and should be questioned. The Hormone Shop LLC specifically assumes no liability for any comment or advice appearing in the "Discussion Forum".
Notice: This information on anti-aging
provided for educational and nutritional purposes. Any medical procedures,
dietary changes or the use of dietary supplements discussed herein should only
be undertaken on the advice of a qualified medical doctor. Although listed and
sold as dietary supplements these are not innocuous, inert substances; rather they can and
do affect vital systems within the human body and it is for this reason that you
are urged to find a medical doctor who will work with you in monitoring and
maintaining your well being.