|
Home
Sitemap
How to Order
Secure Order Form
Contact Us
Product Information
5-HTP
5-HTP Library
Acetylcholine
Acetyl-L-Carnitine
Alluna™
Alpha-Lipoic
Acid
Amino Acids
Amoxicillin
AndrosteDERM
Androstat
Apomorphine
Arginine
Books
Books
on Menopause
Cialis
- Generic
Citicoline
CoQ-10
DHA
DHEA
Dim (Diindolylmethane)
Ephedra Ban
Erectile Dysfunction Package
Erections
First Aid
Folic Acid
Gamma-Oryzanol
Generic
Drugs
Ginko Biloba
Glutamine
hGH-PH Complex
Histidine
Hops
Horny Goat Weed
Human Sexuality
Hyaluronic Acid
Impotence
IP-6
LI 160 St. John's Wort
Levitra
- Generic
MSM
Melatonin
Natural V
Niacin, Sustained Release
NorAndrosteDERM
Neuro-DHA
Passion Flower
Pregnenolone
Progesterone Cream
Progesterone, Natural
Projuvine
Progesterone in
Vitamin E Oil
Progesterone-Transdermal Spray
PRO hGH
PROhGH Sport For Women
Pro Sports Creme
Rejuvine
Resveratrol
Secretagogue-One
Sexual
Dysfunction Pak-Women
Skin Fold Calipers
TransMist™-Progesterone Transdermal Spray
TriBuplex
Valerian Extract
Viagra
- Generic
Vitamin B6
VitaminB12
Vitamin
C, Time Released
Womens Libido
tied to DHEA
General Information
5-HTP Update
About
Pharmasan Labs
Aging: A Specific
Alzheimers
Apomorphine HGH
Body
Temperature & Sleep
Biological Function
Aging
Alternative
Medicine
Beta Blockers
Biological Clocks
Building Muscle Mass in the
Aging
Compounding Pharmacy
Coronary
Heart Disease
DHEA
Depression
Depression, Male
Diindolylmethane DIM
Dreaming
End-of-life
Ephedra Ban
Erectile Dysfunction
Erections
Estrogen
Dominance
Ginkgo Trees, order
Glossary
Growth Hormone Stimulators
Heart Attacks and Neuro DHA
Heart
Clinic, The
Herbs & Botanicals
Herbs - The American Approach
Herbs - The German Approach
Homocysteine
Hormone Balance in the Menopausal Female
Hormone Replacement Therapy
Human Growth Hormone
Hormone Replacement Library - Women
Impotence
Insomnia
IP-6 Inositol Hexaphosphate
IP6 Gov Report
Lukemia & HGH
Library 5-HTP
Library - HRT
Light
Lupus & DHEA, From The
FDA:
Mania
Menopause
Therapy-News
Natural V
Testosterone
Pain
Penis Enlargement - Facts and Fiction
Perimenopause
Pituitary Gland
Progesterone
Progesterone
Deficiency
Progesterone-The Real story
ProHormones
Resveratrol
Sexual
dysfunction-Women
Sexual Dysfunction-Men
Sirtuins
Sleep Clinic, The
Suicide
Telomerase
Temperature,
Body & Sleep
Testosterone For
Women
Testosterone & Men
Testosterone
Dominance
Testosterone &
Women
Testosterone, Maintaining Levels
Vitamin
C, Time Released
Vitamins,
Minerals & Amino Acids
Woman's
Body, Image & Health
Womens Libido
tied to DHEA
| |
More on Nattokinase:
| Purchase
|:90 capsules x 100 mg from Health Freedom Nutrition: $69.95
| Purchase
|:60 capsules x 100 mg $36.78
Powerful Enzyme Prevents Heart Attack and Stroke
Cardiovascular disease is the leading cause of death for men and women
According to the U.S. Centers for Disease Control, each year about 700,000
people suffer a stroke, the leading cause of serious, long-term disability in
the United States. The American Heart Association estimates that in 2004, more
than 1 million Americans will suffer a heart attack. About 700,000 of these will
be first-time heart attack sufferers, while approximately 500,000 will be people
who have previously had a heart attack. It all adds up to this: contrary to
popular belief, heart attack and stroke account for more deaths than all cancers
and injuries combined, and one out of every 2.4 deaths is attributable to
cardiovascular disease. How is that possible in the richest, most highly
educated country on earth?
We all get too little exercise, accumulate too much stress, and eat a poor diet
laden with saturated fat, refined sugar and too little fiber. Add to that list
the habit of smoking and the answer is quite clear. (Although there is a
considerably higher prevalence of cigarette smoking in Japan than in the U.S.,
mortality from CVD among men in Japan is still less than half of that in the
U.S.3) And to make matters worse, a study published in The Journal of the
American Medical Association (3/6/2002) indicates that exposure to air pollution
can cause some 10,000 fatal heart attacks a year in the U.S.!
Mainstream health care has banded together with the pharmaceutical industry to
offer a temporary quick fix for the number one killer of our time. Statin drugs
reduce cholesterol. Aspirin and Warfarin, thin the blood. Anti-hypertension
medications reduce blood pressure. Bypass surgery, and angioplasty clear the
arteries. Essentially, they all help prolong the life of a patient with
cardiovascular disease (CVD). But none of these drugs or procedures is without
risk or side effects. Well, we've got good news for you!
CVD risk can be greatly reduced by modifying lifestyle and adding nutritional
supplements proven to support cardiovascular health. Most of us are aware that
eating a lighter, more balanced diet, quitting tobacco and exercising regularly
are enough to head off most cases of heart disease before they ever happen. Now
there's something else you can do.
Nattokinase has been shown to support normal blood pressure, dissolve blood
clots and prevent them from forming in the first place!
What Is Nattokinase?
Nattokinase is a potent fibrinolytic (anti-clotting) enzyme complex extracted
and highly purified from a traditional Japanese food called Natto. Natto is a
fermented cheese-like food that has been used in Japanese culture for more than
1000 years for its popular taste, and as a folk remedy for heart and vascular
diseases. Research has shown that Nattokinase supports the body in breaking up
and dissolving the unhealthy coagulation of blood. In fact, it has been shown to
have four times greater fibrinolytic activity than plasmin.4
How is it made?
Natto is produced by a fermentation process by adding the bacteria Bacillus
subtilis to boiled soybeans. The resulting Nattokinase enzyme is produced
when Bacillus subtilis acts on the soybeans. While other soy foods
contain enzymes, it is only the natto preparation that contains the specific
Nattokinase enzyme. How was Nattokinase discovered? Japanese researcher Dr.
Hiroyuki Sumi had spent many years searching for a natural thrombolytic agent
that could successfully dissolve blood clots associated with heart attacks and
stroke. Finally in 1980, after testing more than 173 natural foods, Sumi found
what he was looking for.
Natto, a traditional Japanese soy cheese, was dropped onto an artificial
thrombus (fibrin) in a petri dish and allowed to stand at 37ºC (approximately
body temperature). Over the next 18 hours, the thrombus around the natto
completely dissolved! Sumi named the newly discovered enzyme Nattokinase, which
means "enzyme in natto." Dr. Sumi remarked that Nattokinase showed
"a potency matched by no other enzyme." 5,6
How blood clots form
Blood clotting is a natural process that allows the blood to thicken and form a
clot or thrombus of blood cells. When a blood vessel is injured, platelets clump
together and strands of the blood protein fibrin glue them together in order to
stop the bleeding. Eventually the clot helps form a protective scab over a
healing wound. If our bodies did not have the ability to clot blood, we would
bleed to death after even a minor cut, which was often the case with
hemophiliacs.
But sometimes blood clots form even when a person has not been wounded or cut.
Although most blood clots naturally dissolve on their own without complications,
there are two situations in which they can wreak havoc before they are
reabsorbed by the body.
- A thrombus can form in an artery which could block the flow of blood and
cut off oxygen supply. This can trigger a heart attack and result in damage,
destruction (infarction), or even death of the tissues (necrosis) in the
heart. In the brain, blood clots also block blood and oxygen from reaching
necessary areas, which can result in senility and/or stroke.5
- A piece of the blood clot could form in one of the heart's chambers and
then travel through the bloodstream, lodging in either an organ or an artery
and cutting off the blood supply from that point, causing an embolism. An
embolism is especially dangerous when it ends up in a lung.
The most common cause of these emboli are blood clots that form during atrial
fibrillation. This is a disorder found in about 2 million Americans. In atrial
fibrillation the heart's two small upper chambers (the atria) quiver instead of
beating effectively. Some blood isn't pumped completely out of them when the
heart beats, so it pools and clots. When a blood clot enters the circulation and
lodges in a narrowed artery of the brain, a stroke occurs.
The chances of developing thrombi increase as we age
Although the human body produces more than 20 enzymes for making blood clots, it
produces only one enzyme—plasmin—for dissolving them. The problem is, as we
age the production of plasmin slows down, making the blood more prone to
coagulation. And since plasmin is produced by endothelial cells throughout the
body, it is possible to develop blood clots anywhere in the body.
To make matters worse, fibrinogen levels rise as we age.7
And high levels of fibrinogen levels usually lead to increased platelet
aggregation, blood clots, and eventually heart attack or stroke. In fact, high
fibrinogen levels are considered a more dangerous risk factor for heart attack
and stroke than high cholesterol. A study of 2,116 men found that those with
high LDL (bad) cholesterol but low fibrinogen levels had only one sixth the risk
for heart attack than the men with low LDL and high fibrinogen.8
How does it work
Nattokinase enhances the body's natural ability to fight blood clots, and has an
advantage over blood thinners because it has a prolonged effect without side
effects.
Nattokinase:
 | supports normal blood pressure
| prevents blood clots from forming
| dissolves existing blood clots
| dissolves fibrin
| enhances the body's production of plasmin and other clot-dissolving
agents, including urokinase |
| | | |
Research studies
Nattokinase has been the subject of 17 studies, including two small human
trials. In 1990, Dr. Sumi's research team published a series of studies
demonstrating the fibrinolytic effects of Nattokinase.9 Here
are some of them:
Dissolves blood clots
Researchers from JCR Pharmaceuticals, Oklahoma State University, and Miyazaki
Medical College tested Nattokinase on 12 healthy Japanese volunteers (6 men and
6 women, between the ages of 21 and 55). The researchers gave the volunteers 7
ounces of natto (the food) before breakfast, and then tracked fibrinolytic
activity through a series of blood plasma tests.
In one test, a blood sample was taken and a thrombus (clot) was artificially
induced. The amount of time needed to dissolve the clot was cut in half within 2
hours of treatment, compared to the control group. Additionally, the volunteers
retained an enhanced ability to dissolve blood clots for up to 8 hours.9
Dr. Sumi's team also induced blood clots in a major leg vein in male dogs that
had been given either four capsules of Nattokinase (250 mg per capsule) or four
placebo capsules. Angiograms (x-rays of blood vessels) showed that the blood
clots in the dogs that received Nattokinase had completely dissolved within 5
hours of treatment, and that normal blood circulation had been restored. Blood
clots in the dogs who received the placebo showed no sign of dissolving 18 hours
after the treatment.9
Researchers from Biotechnology Research Laboratories and JCR Pharmaceuticals Co.
of Kobe, Japan, tested Nattokinase's ability to dissolve a blood clot in the
carotid arteries of rats. Animals treated with Nattokinase regained 62 percent
of blood flow, whereas those treated with plasmin regained just 15.8 percent of
blood flow.1,9
In another laboratory study, endothelial damage was induced in the femoral
arteries of rats that had been given Nattokinase. In normal circumstances, a
thickening of the artery walls and blood clotting would occur, but they were
both suppressed because of Nattokinase's fibrinolytic activity.10
Helps reduce high blood pressure
Human volunteers with high blood pressure were given 30 grams of natto extract
(equivalent to 7 ounces of natto food), orally for 4 consecutive days. In 4 out
of 5 volunteers, the systolic blood pressure decreased on average from 173.8 to
154.8. Diastolic blood pressure decreased on average from 101.0 to 91.2. This
data represents about a 10.9 percent drop in systolic blood pressure and a 9.7
percent drop in diastolic blood pressure.5,9,11
Wistar rats that were given natto extract showed a significant drop in systolic
blood pressure also, from an average of 166 to 145 in just two hours, which
further decreased to an average of 144 in 3 hours. This data represents an
approximate 12.7 percent drop in systolic blood pressure also, from an average
of 166 to 145 in just two hours, which further decreased to an average of 144 in
three hours. This data represents an approximate 12.7 percent drop in systolic
blood pressure within two hours..5,9,11
These tests all indicate that Nattokinase generates a heightened ability in the
body to dissolve blood clots.
Restores blood circulation
This is one of the most dramatic, documented stories about the effects of
Nattokinase. A 58-year-old man had a blood clot in the retina of his right eye
that caused fluid build up and bleeding. He started losing his vision in that
eye and was admitted to a university hospital, where researchers prescribed a
3-ounce dose of natto to be taken before bed every night, in order to get the
benefit of Nattokinase.
The man's bleeding completely stopped by the tenth day, and by the 20th day, his
vision returned and he was released from the hospital. He continued to eat natto
twice a week. When he had a retinal angiogram two months later, it showed that
the blood clot was completely gone.12
Is Nattokinase for everyone?
This soy extract is considered extremely useful for those wanting a safe,
drugless, non-aspirin alternative for healthy blood flow. Nattokinase is also a
safe alternative for those who are off their feet because of illness, injury
(including paralysis), or surgery.
Excellent for periods of inactivity
In the past few years, medical professionals began alerting the public about the
increasing evidence that long flights and car trips put people at risk for deep
vein thrombosis (DVT)—a blood clot that develops in a deep vein, usually in
the leg. DVT is more common in women than in men, and in those over 40 years of
age.
Deep vein thrombosis
DVT—blood clots inside veins found deep in extremities or body cavities—is a
common disorder. A venous thrombus is a clump of blood cells, platelets, and
fibrin (clot) which attaches to the inside walls of veins, can grow in size, and
break off to travel downstream from the clot. If the clot stays localized, it
can cause swelling and vein irritation. If part of it breaks off, it can cause
blockage downstream, or become an embolus and result in a pulmonary embolus. In
some instances, deep vein thrombosis may also contribute to other serious
medical problems such as heart attack and stroke.
How safe is Nattokinase?
It is very safe when used according to the recommended dosage. People with
ulcers, recent or pending surgery, or recent major trauma should not take
Nattokinase. Anyone who has ever had neurosurgery or ischemic stroke in the
previous six months should not take Nattokinase, as well as those who have had
intracranial bleeding. Generally, people with bleeding disorders, or taking
anti-clotting medication, should use this product only under the close
supervision of a medical doctor.
Researchers have found that Nattokinase is four times more potent than plasmin,
and works even more effectively than Warfarin drugs because it continues to work
for long periods of time, and it doesn't produce any side effects.
Conclusion
The traditional Japanese food Natto has been used safely for more than 1,000
years. The safety record of its potent fibrinolytic enzyme, Nattokinase, is
based upon the long-term traditional use of the food, and recent scientific
studies.
Nattokinase has many benefits including its prolonged effects, cost
effectiveness, and its ability to be used preventatively. It is a naturally
occurring, food-based dietary supplement that has demonstrated stability in the
gastrointestinal tract, as well as to changes in pH and temperature. It is
definitely a nutritional supplement to consider adding to a cardiovascular
health maintenance plan.
References:
- Soy intake shown to reduce mortality
rate from cancer and CVD. Nagata C. Ecological study of the association
between soy product intake and mortality from cancer and heart disease in
Japan. Int J Epidemiol. 2000 Oct;29(5):832-6.
Abstract
- Fujita M, Nomura K, Hong K, Ito Y, Asada
A, Nishimuro S. Biochem Biophys Res Commun 1993 Dec 30;197(3):1340-7
Biotechnology Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe,
Japan.
Abstract
- Clinical trials.gov. Epidemiology of
Coronary Heart Disease in Men Aged 40 and Over. August 2004. National
Institutes of Health. Sept. 13, 2004
http://www.clinicaltrials.gov/ct/show/NCT00069797?order=31
- Suzuki Y, Kondo K, Ichise H, Tsukamoto
Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans
suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4.
Abstract
- Prevent Heart Attack and Stroke with
Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences
Institute, March 2002.
- Hager, K. et al. Fibrinogen and Aging. Aging
(Milano) 1994, 6:133-38.
Abstract
- Heinrich, J. et al. Fibrinogen and
factor VII in the prediction of coronary risk. Arterioscler Thromb
1994, 14:54-59.
Abstract
- Sumi H. Interview With Doctor of
Medicine Hiroyuki Sumi. Japan Bio Science Laboratory Co. Ltd.
- Sumi, H. et al. "Enhancement of the
fibrinolytic activity in plasma by oral administration of nattokinase."
Acta haematol 1990, 84: 139-43.
Abstract
- Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ,
Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary
supplementation of fermented soybean, natto, suppresses intimal thickening
and modulates the lysis of mural thrombi after endothelial injury in rat
femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98.
Abstract
- Maruyama M, Sumi H. Effect of Natto
Diet on Blood Pressure. JTTAS, 1995.
- Nishimura, K. et al. Natto diet was
apparently effective in a case of incipient central retinal vein occlusion. Japan
Rev Clin Ophthalmol 1994, 88:1381-85.
| |
|
